![](/StructureFile/ChemBookStructure9/GIF/CB2113966.gif)
3-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)BENZENECARBOHYDRAZIDE synthesis
- Product Name:3-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)BENZENECARBOHYDRAZIDE
- CAS Number:923224-97-9
- Molecular formula:C11H15N3O3S
- Molecular Weight:269.32
![METHYL 3-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)BENZENECARBOXYLATE](/StructureFile/ChemBookStructure8/GIF/CB3172999.gif)
900015-34-1
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![3-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)BENZENECARBOHYDRAZIDE](/StructureFile/ChemBookStructure9/GIF/CB2113966.gif)
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Yield:923224-97-9 31%
Reaction Conditions:
with hydrazine in methanol at 65; for 12 h;
Steps:
51 PREPARATION OF 3-(1 ,1 -DIOXIDOTHIOMORPHOLINO)BENZOHYDRAZIDE.
Methyl 3-(1 ,1-dioxidothiomorpholino)benzoate (95 mg, 0.353 mmol) was addedto the hydrazine (22.61 mg, 0.705 mmol) in methanol and refluxed for 12 h at 65 °C. Following cooling, Reaction was monitored by TLC. After completion of the reaction, the solvent was removed by vacuum and then compound was purified by column chromatography (2% CH30H/CH2CI2) afforded the title compound 3- (1 ,1 -dioxidothiomorpholino)benzohydrazide (32 mg, 0.109 mmol, 31.0 % yield) as a solid. 1 H NMR (CDCI3, 400 MHz): δ 7.34 (m, 1 H), 7.29 (t, 1 H, J = 8.4 Hz), 7.18 (d, 1 H, J = 7.6 Hz), 6.70 (dd,1 H, J = 4.8 & 8.0 Hz), 3.85 (m, 4H), 3.05 (m, 4H). Mass [M+H]+ :270.1
References:
WO2013/25805,2013,A1 Location in patent:Paragraph 00266
![3-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)BENZENECARBOXYLIC ACID](/StructureFile/ChemBookStructure8/GIF/CB3753651.gif)
763073-96-7
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![3-(1,1-DIOXO-1LAMBDA6,4-THIAZINAN-4-YL)BENZENECARBOHYDRAZIDE](/StructureFile/ChemBookStructure9/GIF/CB2113966.gif)
923224-97-9
7 suppliers
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