4-Quinolinol, 8-chloro-7-methoxy-2-[4-(1-methylethyl)-2-thiazolyl]- synthesis

Yield:-

Reaction Conditions:

with potassium tert-butylate in tert-butyl alcohol at 100;

References:

Raboisson, Pierre;de Kock, Herman;Rosenquist, Asa;Nilsson, Magnus;Salvador-Oden, Lourdes;Lin, Tse-I;Roue, Natalie;Ivanov, Vladimir;Waehling, Horst;Wickstroem, Kristina;Hamelink, Elizabeth;Edlund, Michael;Vrang, Lotta;Vendeville, Sandrine;Van de Vreken, Wim;McGowan, David;Tahri, Abdellah;Hu, Lili;Boutton, Carlo;Lenz, Oliver;Delouvroy, Frederic;Pille, Geert;Surleraux, Dominique;Wigerinck, Piet;Samuelsson, Bertil;Simmen, Kenneth [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 17,p. 4853 - 4858] Location in patent:scheme or table