N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-2-MORPHOLINOACETAMIDE synthesis
- Product Name:N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]-2-MORPHOLINOACETAMIDE
- CAS Number:92494-47-8
- Molecular formula:C15H16ClN3O2S
- Molecular Weight:337.82
![2-CHLORO-N-[4-(4-CHLOROPHENYL)-1,3-THIAZOL-2-YL]ACETAMIDE](/StructureFile/ChemBookStructure2/GIF/CB3667406.gif)
Yield:92494-47-8 65%
Reaction Conditions:
in toluene;Reflux;
Steps:
2-[2-(Substituted amino)acetamido- or 3-(substituted amino)propanamido]-4-(4-chlorophenyl)-1,3-thiazoles (20-25).
General procedure: To a stirred solution of 18, 19 (0.01 mol) in dry toluene (50 ml), the appropriate amine (0.04 mol) was added dropwise. The reaction mixture was heated under reflux for 3-5 h. and continued as mentioned under compounds 11-16, (Table 1).
References:
Hassan, Ghada S.;El-Messery, Shahenda M.;Al-Omary, Fatmah A.M.;El-Subbagh, Hussein I. [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 20,p. 6318 - 6323] Location in patent:supporting information
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