ChemicalBook CAS DataBase List tert-butyl 6-nitro-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

tert-butyl 6-nitro-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate synthesis

3synthesis methods

Product Name:tert-butyl 6-nitro-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate
CAS Number:928118-23-4
Molecular formula:C13H16N2O5
Molecular Weight:280.28

24424-99-5 Synthesis

24424-99-5
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28226-22-4
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tert-butyl 6-nitro-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

928118-23-4
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Yield:928118-23-4 74%

Reaction Conditions:

with dmap in acetonitrile;Heating / reflux;

Steps:

38.1

A solution of compound 3C (14.1 g, 78 mmol) in MeCN (200 mL) was treated with (BOC)₂O (20.5 g, 94 mmol) and DMAP (0.5 g) and then refluxed overnight. The reaction mixture was concentrated and chromatographed (10% -50% EtOAc/hexanes) to give compound 38A (16.1 g, 74%, typically 70-90%) and recovered starting material 3C.

References:

US2007/93477,2007,A1 Location in patent:Page/Page column 43

99-57-0
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$22.00/25g

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References

81721-87-1 Synthesis

81721-87-1
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$16.00/500mg

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References