Bicyclo[2.2.2]octane-1-carboxiMidaMide, N-hydroxy-4-[4-Methyl-5-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-3-yl]- synthesis

Yield:-

Reaction Conditions:

with hydroxylamine in ethanol;water at 80; for 18 h;

Steps:

1.F

Step F:A solution of nitrile 1-F (0.56 g, 1.6 mmol) and hydroxylamine (50% aqueous, 4 ml) in ethanol (40 ml) was heated at 80° C. for 18 h. The resulting mixture was cooled to room temperature and concentrated in vacuo. The solid was suspended in toluene, the solvent removed in vacuo, and the solid (1-G) was dried under reduced pressure, and used in the next step without further purification.

References:

US2008/262051,2008,A1 Location in patent:Page/Page column 11; 12