2-(Dimethylamino)-6-(trifluoromethyl)nicotinonitrile synthesis
- Product Name:2-(Dimethylamino)-6-(trifluoromethyl)nicotinonitrile
- CAS Number:935518-01-7
- Molecular formula:C9H8F3N3
- Molecular Weight:215.18
680-31-9
443 suppliers
$14.00/25g
386704-06-9
127 suppliers
$11.00/250mg
935518-01-7
4 suppliers
inquiry
Yield:935518-01-7 100%
Reaction Conditions:
at 150; for 48 h;
Steps:
14.i; 69
To 2-chloro-6-(trifluoromethyl)nicotinonitrile (0.8g, 3.8 mmol) was added hexamethylphosphoramide (6 mol eq, 4.16 mL) and the mixture was heated at 150°C for 48h. The reaction mixture was cooled at room temperature, water and brine were added and the mixture was extracted with EtOAc (4x35 mL). The recombined organic phases were dried over sodium sulfate and evaporated to dryness to obtain 28d as yellow oil (l .Olg, quantitative yield). 1HNM (DMSO, 200 MHz) δ 1.33 (s, 3H), 1.38 (s, 3H), 7.41 (d, 1H, J=6), 7.55 (d, 1H, J=6).
References:
WO2011/120604,2011,A1 Location in patent:Page/Page column 104; 137
116548-04-0
67 suppliers
inquiry
935518-01-7
4 suppliers
inquiry
386704-06-9
127 suppliers
$11.00/250mg
124-40-3
498 suppliers
$18.00/100ml
935518-01-7
4 suppliers
inquiry