2-[(TERT-BUTOXY)CARBONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXYLIC ACID(WX142476) synthesis
- Product Name:2-[(TERT-BUTOXY)CARBONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXYLIC ACID(WX142476)
- CAS Number:936829-00-4
- Molecular formula:C15H19NO4
- Molecular Weight:277.32
24424-99-5
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Yield:936829-00-4 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20;
Steps:
22.A Step A: Preparation of 2-(tert-butoxycarbonyl - 1,2,3, 4-tetrahvdroisoquinoline-4- carboxylic acid.
l,2,3,4-tetrahydroisoquinoline-4-carboxylic acid (530 mg, 2.99 mmol), Boc20 (685 mg, 3.14 mmol) and NEt3 (1251 μ, 8.97 mmol) were combined in DCM (20 mL) and stirred at ambient temperature overnight. The reaction was poured into IN HC1 (20 mL), the layers were separated and the aqueous layer was extracted with EtOAc (2x25 mL). The combined organic extracts were dried (MgS04) and concentrated to provide the title compound (830 mg, 2.99 mmol, 100 % yield). MS (apci) m/z = 178.1 (M+H-Boc).
References:
WO2014/78454,2014,A1 Location in patent:Paragraph 00835
936828-99-8
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936829-00-4
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24424-99-5
833 suppliers
$13.50/25G
936829-00-4
15 suppliers
inquiry