Benzeneacetonitrile, α-hydroxy-α-(trifluoromethyl)- synthesis
- Product Name:Benzeneacetonitrile, α-hydroxy-α-(trifluoromethyl)-
- CAS Number:93923-55-8
- Molecular formula:C9H6F3NO
- Molecular Weight:201.15
Yield:93923-55-8 99%
Reaction Conditions:
Stage #1: trimethylsilyl cyanide;2,2,2-Trifluoroacetophenonewith zinc(II) iodide in dichloromethane at 20; for 4 h;
Stage #2: with hydrogenchloride in tetrahydrofuran;dichloromethane at 0 - 20; for 2 h;
References:
Choudhury-Mukherjee, Indrani;Schenck, Hilary A.;Cechova, Sylvia;Pajewski, Thomas N.;Kapur, Jaideep;Ellena, Jeffrey;Cafiso, David S.;Brown, Milton L. [Journal of Medicinal Chemistry,2003,vol. 46,# 12,p. 2494 - 2501]
434-45-7
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