![](/CAS/GIF/941685-27-4.gif)
4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine synthesis
- Product Name:4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
- CAS Number:941685-27-4
- Molecular formula:C15H21N5OSi
- Molecular Weight:315.45
![4-Pyrazoleboronic acid pinacol ester](/CAS/GIF/269410-08-4.gif)
269410-08-4
384 suppliers
$5.00/1g
![4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE](/CAS/GIF/941685-26-3.gif)
941685-26-3
168 suppliers
$59.00/250mg
![4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/941685-27-4.gif)
941685-27-4
234 suppliers
$18.00/250mg
Yield:941685-27-4 166.4 g
Reaction Conditions:
Stage #1:pyrazole-4-boronic acid pinacol ester;4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine with potassium carbonate in water at 25 - 30;Inert atmosphere;
Stage #2: with tetrakis(triphenylphosphine) palladium(0) at 78 - 80; for 2 h;Inert atmosphere;
Steps:
1.b Preparation of 4-(lH-pyrazol-4-yl)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H- pyr rolo [2,3-d] pyrimidine References:
SUN PHARMACEUTICAL INDUSTRIES LIMITED;CHAWLA, Deepshikha;BARMAN, Dhiren, Chandra;CHATTERJEE, Pranab;NATH, Asok;PRASAD, Mohan WO2016/35014, 2016, A1 Location in patent:Page/Page column 27
Nitrogen gas was purged through a mixture of 4-chloro-7- { [2- (0224) (trimemylsilyl)ethoxy]memyl}-7H-pyIτolo[2,3-
![1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-[7-[[2-(triMethylsilyl)ethoxy]Methyl]-7H-pyrrolo[2,3-d]pyriMidin-4-yl]-, (βS)-](/CAS/20211123/GIF/941685-41-2.gif)
941685-41-2
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![4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/941685-27-4.gif)
941685-27-4
234 suppliers
$18.00/250mg
![4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](/CAS/20180702/GIF/1187595-88-5.gif)
1187595-88-5
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![4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/941685-27-4.gif)
941685-27-4
234 suppliers
$18.00/250mg
![4-CHLORO-7-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-7H-PYRROLO[2,3-D]PYRIMIDINE](/CAS/GIF/941685-26-3.gif)
941685-26-3
168 suppliers
$59.00/250mg
![1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole](/CAS/GIF/1029716-44-6.gif)
1029716-44-6
274 suppliers
$6.00/250mg
![4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/941685-27-4.gif)
941685-27-4
234 suppliers
$18.00/250mg
![1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-[7-[[2-(triMethylsilyl)ethoxy]Methyl]-7H-pyrrolo[2,3-d]pyriMidin-4-yl]-](/CAS/20180808/GIF/941685-39-8.gif)
941685-39-8
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![4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/941685-27-4.gif)
941685-27-4
234 suppliers
$18.00/250mg