1-Piperidinecarboxylic acid, 2-(2-methylpropyl)-4,6-dioxo-, 1,1-dimethylethyl ester synthesis

2synthesis methods

Product Name:1-Piperidinecarboxylic acid, 2-(2-methylpropyl)-4,6-dioxo-, 1,1-dimethylethyl ester
CAS Number:942425-70-9
Molecular formula:C14H23NO4
Molecular Weight:269.34

2033-24-1 Synthesis

2033-24-1
629 suppliers
$6.00/25g

3-[(T-BUTOXYCARBONYL)AMINO]-5-METHYLHEXANOICACID

138165-75-0
44 suppliers
$45.00/50mg

1-Piperidinecarboxylic acid, 2-(2-methylpropyl)-4,6-dioxo-, 1,1-dimethylethyl ester

942425-70-9
0 suppliers
inquiry

Yield:942425-70-9 72%

Reaction Conditions:

with dmap;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane at 20; for 3 h;

Steps:

2.2

To a stirred solution of 3-(tert-butoxycarbonylamino)-5-methylhexanoic acid (44.0 g, 0.179 mol) in DCM (800 mL) at 0° C., EDC hydrochloride (51.56 g, 0.269 mol), DMAP (32.8 g, 0.269 mol) and Meldrum's acid (25.8 g, 0.179 mol) were added. The reaction mixture was stirred at room temperature for 3 h, washed with 1 N KHSO₄(500 mL), dried over Na₂SO₄and concentrated. The residue was dissolved in dry ethyl acetate (1.5 L) and heated under reflux overnight. The reaction mixture was washed with 1 N KHSO₄(500 mL), brine (500 mL), dried over Na₂SO₄and concentrated. The residue was purified by column chromatography using petroleum ether and EtOAc (65:35) as eluent to yield 3-(tert-butoxycarbonylamino)-5-methylhexanoic acid as a solid (35 g, 72%).

References:

US2010/261755,2010,A1 Location in patent:Page/Page column 13

3653-34-7 Synthesis

3653-34-7
85 suppliers
$9.00/250mg

24424-99-5 Synthesis

24424-99-5
825 suppliers
$13.50/25G

942425-70-9
0 suppliers
inquiry

References