ChemicalBook CAS DataBase List 4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide

4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide synthesis

5synthesis methods

Product Name:4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide
CAS Number:94345-47-8
Molecular formula:C21H28N4O2
Molecular Weight:368.47

Benzonitrile, 4,4'-[1,7-heptanediylbis(oxy)]bis-

224054-32-4
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4-[7-(4-carbamimidoylphenoxy)heptoxy]benzenecarboximidamide

94345-47-8
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Yield:94345-47-8 86%

Reaction Conditions:

Stage #1: 4,4′-(heptane-1,7-diylbis(oxy))dibenzonitrilewith lithium hexamethyldisilazane in tetrahydrofuran at 20;Inert atmosphere;
Stage #2: with hydrogenchloride in tetrahydrofuran at 0 - 20;

References:

Wesseling, Charlotte M. J.;Slingerland, Cornelis J.;Veraar, Shanice;Lok, Samantha;Martin, Nathaniel I. [ACS Infectious Diseases,2021,vol. 7,# 12,p. 3314 - 3335]

767-00-0 Synthesis