1-(3-methoxyphenyl)-1H-1,2,3-triazole-4-carboxylic acid synthesis

6synthesis methods

Product Name:1-(3-methoxyphenyl)-1H-1,2,3-triazole-4-carboxylic acid
CAS Number:944901-61-5
Molecular formula:C10H9N3O3
Molecular Weight:219.2

1H-1,2,3-Triazole-4-carboxylic acid, 1-(3-methoxyphenyl)-, ethyl ester

1126635-91-3
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1-(3-methoxyphenyl)-1H-1,2,3-triazole-4-carboxylic acid

944901-61-5
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Yield:944901-61-5 97.9%

Reaction Conditions:

Stage #1: ethyl 1-(3-methoxyphenyl)-1H-1,2,3-triazole-4-carboxylatewith sodium hydroxide in methanol;water at 20;Inert atmosphere;
Stage #2: with hydrogenchloride in water; pH=5 - Ca. 6;Inert atmosphere;

References:

Bai, Suping;Li, Shihong;Xu, Jinbin;Peng, Xin;Sai, Kiran;Chu, Wenhua;Tu, Zhude;Zeng, Chenbo;Mach, Robert H. [Journal of Medicinal Chemistry,2014,vol. 57,# 10,p. 4239 - 4251] Location in patent:supporting information

3866-16-8 Synthesis