1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, ETHYL ESTER synthesis

1synthesis methods

Product Name:1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, ETHYL ESTER
CAS Number:945865-21-4
Molecular formula:C16H21BN2O4
Molecular Weight:316.16

942920-55-0 Synthesis

ethyl 4-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

942920-55-0
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73183-34-3
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1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, ETHYL ESTER

945865-21-4
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Yield:945865-21-4 68%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in N,N-dimethyl-formamide at 90; for 48 h;Suzuki coupling;

References:

Tang, Jun;Hamajima, Toshihiro;Nakano, Masato;Sato, Hideyuki;Dickerson, Scott H.;Lackey, Karen E. [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 16,p. 4610 - 4614] Location in patent:scheme or table