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(3aR,6aR)-Pyrrolo[3,4-b]pyrrole-5(1H)-carboxylic acid hexahydro ethyl ester synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: hydrogen / 5% Pd(OH)2/C / methanol; water / 4 h / 50 °C / 2068.65 Torr
2: methanol / 2 h / 55 - 65 °C
3: potassium hydroxide; water / dichloromethane / 2.75 h / 0 °C

References:

WO2007/100990,2007,A2