1-CYCLOPENTYLPIPERIDINE-4-CARBOXYLIC ACIDHYDROCHLORIDE synthesis

Yield:953077-13-9 39%

Reaction Conditions:

with hydrogenchloride;water at 100; for 16 h;

Steps:

4.1.2

4.1.2) 1-cyclopentyl-piperidine-4-carboxylic acid hydrochloride 30.00 g (133.140 mmol) ethyl 1-cyclopentyl-piperidine-4-carboxylate and 150 mL conc. hydrochloric acid are placed in 150 mL water, then stirred for 16 hours at 100° C. The reaction mixture is concentrated in vacuo, during which time a precipitate is formed. This is suction filtered and dried. Yield: 12.1 g (39%)

References:

US2007/238718,2007,A1 Location in patent:Page/Page column 22