ChemicalBook CAS DataBase List (S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one

(S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one synthesis

5synthesis methods

Product Name:(S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one
CAS Number:953805-20-4
Molecular formula:C25H28FNO5
Molecular Weight:441.49

126-30-7 Synthesis

126-30-7
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189028-93-1 Synthesis

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

189028-93-1
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(S)-3-(4-(2-(4-fluorophenyl)-5,5-diMethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one

953805-20-4
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Yield:953805-20-4 89%

Reaction Conditions:

with phosphorus pentoxide;sulfuric acid in dichloromethane; for 5 h;Reflux;

Steps:

3 Synthesis of Compound III (wherein R1 = R2 = CH3)

Compound II (35.5 g, 0.1 mol) was added to a 500 ml three-necked flask, 200 ml of dichloromethane, Then, 2,2-dimethyl-1,3-propanediol (15.6 g, 0.15 mol), phosphorus pentoxide (14.2 g, 01 mol) and concentrated sulfuric acid (0.98 g, 0.01 mol) Reflux reaction for 5 hours, After the reaction, the ice bath cools down, And then adjusted to pH 7 with saturated aqueous sodium bicarbonate solution, Static stratification, Dichloromethane layer washed, Dried over anhydrous sodium sulfate, Concentrated to dry, To give 41.2 g of a white solid compound III, Yield 89%.

References:

CN106397292,2017,A Location in patent:Paragraph 0053; 0089; 0090