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953900-08-8

2-(4-CHLORO-2-METHYLPHENOXY)PYRIDINE-3-CARBOXYLIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: caesium carbonate / N,N-dimethyl acetamide / 48 h / 120 °C
2: water; lithium hydroxide / tetrahydrofuran / 4 h / 100 °C

References:

Koltun, Elena;Richards, Steven;Chan, Vicky;Nachtigall, Jason;Du, Hongwang;Noson, Kevin;Galan, Adam;Aay, Naing;Hanel, Art;Harrison, Amanda;Zhang, Jeff;Won, Kwang-Ai;Tam, Danny;Qian, Fawn;Wang, Tao;Finn, Patricia;Ogilvie, Kathleen;Rosen, Jon;Mohan, Raju;Larson, Christopher;Lamb, Peter;Nuss, John;Kearney, Patrick [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 22,p. 6773 - 6777]