4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanoic acid(SALTDATA: FREE) synthesis

8synthesis methods

Product Name:4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanoic acid(SALTDATA: FREE)
CAS Number:95494-51-2
Molecular formula:C12H12N2O3
Molecular Weight:232.24

108-55-4 Synthesis

108-55-4
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Benzenecarboximidic acid, 2-amino- (9CI)

28144-70-9
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4-(4-oxo-3,4-dihydroquinazolin-2-yl)butanoic acid(SALTDATA: FREE)

95494-51-2
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$293.00/500mg

Yield:95494-51-2 88.3%

Reaction Conditions:

in toluene; for 3 h;Reflux;

Steps:

1.1 Example 1: Pilot synthesis process of SPAM1 (two-step method)

As shown in Figure 1, a two-step synthesis is used. Step 1: In a 150 mL flask equipped with a condenser, benzamide A (5.45 g, 40.0 mmol, 1.0, etc.) and amber hydride B (4.00 g, 40.0 mmol, 1.0, etc.) are mixed with 50 mL of toluene in. The suspension was refluxed vigorously for 3 hours and then cooled to room temperature. The resulting product C was a white solid which was filtered, washed with Et2O and dried (8.833 g, yield 88.3%). The product NMR detection is shown in Figure 2.

References:

CN111533702,2020,A Location in patent:Paragraph 0037-0038

Pentanoic acid, 5-[(2-cyanophenyl)amino]-5-oxo-

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95494-51-2
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References

5-{[2-(aminocarbonyl)phenyl]amino}-5-oxopentanoic acid

197236-49-0
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95494-51-2
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References

108-55-4 Synthesis

108-55-4
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95494-51-2
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$293.00/500mg

References

1885-29-6
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95494-51-2
19 suppliers
$293.00/500mg

References