"4,4-Dihydroxy-4,5,6,7-tetrahydro-indazole-1-carboxylic acid tert-butyl ester hydrate" synthesis
- Product Name:"4,4-Dihydroxy-4,5,6,7-tetrahydro-indazole-1-carboxylic acid tert-butyl ester hydrate"
- CAS Number:955406-75-4
- Molecular formula:C12H16N2O3
- Molecular Weight:236.27
24424-99-5
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499206-33-6
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955406-75-4
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Yield:955406-75-4 92%
Reaction Conditions:
with dmap in dichloromethane at 20; for 1 h;
Steps:
11; 4.1
Scheme 4, Step 1. To a solution of 6,7-dihydro-lH-indazol-4(5H)-one (0.1 g, 0.734 mmol) in DCM (3.5 ml) were added DMAP (0.108 g, 0.881 mmol) and BOC20 (0.232 ml, 0.999 mmol). The mixture was stirred at r.t. for lh. Evaporation of the solvent and purification by Biotage, eluting with a hexanes-EtOAc gradient, gave title product (0.16g, 92%).
References:
WO2013/78413,2013,A1 Location in patent:Paragraph 0185-0187
504-02-9
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955406-75-4
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$325.00/1g