5,6-Dihydro-4H-cyclopenta[b]-thiophene-2-carbaldehyde synthesis

2synthesis methods

Product Name:5,6-Dihydro-4H-cyclopenta[b]-thiophene-2-carbaldehyde
CAS Number:956010-59-6
Molecular formula:C8H8OS
Molecular Weight:152.21

4H-Cyclopenta[b]thiophene-2-carboxamide, 5,6-dihydro-N-methoxy-N-methyl-

1342217-76-8
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5,6-Dihydro-4H-cyclopenta[b]-thiophene-2-carbaldehyde

956010-59-6
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$39.00/100mg

Yield:956010-59-6 92.1%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at -75 - 25; for 1 h;

Steps:

38.2 Step 2

A suspension of the compound 28b (3.0 g, 14.2mmol) in THF (150 mL) was added LiAlH₄ (0.89 g, 22 mmol) under -75 °C. After then, the temperature was rebound to 25 °C for 1 hour. The mixture was pouring to water, extracted with ethyl acetate. The organic layer was washed with water, brine and dried over Na₂S0₄, concentrated in vacuo to provide compound 28c (2.0 g, 92.1% yield)

References:

WO2014/110688,2014,A1 Location in patent:Page/Page column 103

40133-06-0 Synthesis

5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-2-CARBOXYLIC ACID

40133-06-0
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$58.00/100mg

956010-59-6
22 suppliers
$39.00/100mg

References