(R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride synthesis
- Product Name:(R)-N-(4-(1-aminoethyl)-2,6-difluoro-phenyl)-methanesulfonamide hydrochloride
- CAS Number:956901-23-8
- Molecular formula:C9H13ClF2N2O2S
- Molecular Weight:286.72
956901-22-7
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956901-23-8
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Yield:956901-23-8 94%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;methanol at 20; for 24 h;
Steps:
3.3D
3D) N-{4-[(1R)-1-AMINOETHYL]-2,6-DIFLUOROPHENYL}METHANESULFONAMIDE HYDROCHLORIDE A mixture of the compound of Example 3C (423 mg, 1.1 mmol) and HCl-MeOH (10%, 10 ml) was stirred at room temperature for 24 hours and then concentrated in vacuo. Diethyl ether and MeOH were added to precipitate the amine hydrochloride. The precipitate was then filtered and washed with diethyl ether to furnish the title compound (290 mg, 94%) as a yellow solid.1H NMR (270 MHz, DMSO-d6) δ 1.51 (3H, d, J=6.6 Hz), 3.08 (3H, s), 4.44 (1H, br s), 7.44-7.47 (2H, m), 8.67 (2H, br s), 9.67 (1H, s). MS (ESI) m/z 249 (M-H)-.
References:
US2012/88746,2012,A1 Location in patent:Page/Page column 38
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