Boronic acid, B-[4-[3-(trifluoromethyl)phenoxy]phenyl]- synthesis

3synthesis methods

Product Name:Boronic acid, B-[4-[3-(trifluoromethyl)phenoxy]phenyl]-
CAS Number:958457-42-6
Molecular formula:C13H10BF3O3
Molecular Weight:282.02

401-81-0
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Boronic acid, B-[4-[3-(trifluoromethyl)phenoxy]phenyl]-

958457-42-6
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: tetramethyl-heptanedione; caesium carbonate; copper(l) chloride / 1-methyl-pyrrolidin-2-one / 100 °C
2: n-butyllithium / tetrahydrofuran / -78 °C
3: hydrogenchloride / water / 20 °C

References:

Bueno, José M.;Manzano, Pilar;García, María C.;Chicharro, Jesús;Puente, Margarita;Lorenzo, Milagros;García, Adolfo;Ferrer, Santiago;Gómez, Rubén M.;Fraile, María T.;Lavandera, José L.;Fiandor, José M.;Vidal, Jaume;Herreros, Esperanza;Gargallo-Viola, Domingo [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 18,p. 5214 - 5218]

Benzene, 1-(4-bromophenoxy)-3-(trifluoromethyl)-

109272-29-9
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958457-42-6
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References

106-41-2
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958457-42-6
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References