(S)-DI-TERT-BUTYL 2-(HYDROXYMETHYL)PIPERAZINE-1,4-DICARBOXYLATE synthesis
- Product Name:(S)-DI-TERT-BUTYL 2-(HYDROXYMETHYL)PIPERAZINE-1,4-DICARBOXYLATE
- CAS Number:958635-12-6
- Molecular formula:C15H28N2O5
- Molecular Weight:316.39
788799-69-9
58 suppliers
$42.00/100mg
958635-12-6
19 suppliers
$326.00/1g
Yield:958635-12-6 100%
Reaction Conditions:
Stage #1: (2S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acidwith borane in tetrahydrofuran at 20; for 4 h;Heating / reflux;
Stage #2: with methanol in tetrahydrofuran at 0;
Steps:
3
(S)-2-Piperazine- 1,2,4-tricarboxylic acid 1 ,4-di-te/t-butyl ester (9.90 g, 30.0 mmol) was dissolved in THF (14 mL). IM borane in THF (90 mL, 90.0 mmol) was added at room temperature. The reaction mixture was stirred at reflux for 4 hours and then cooled to 0 0C and quenched with the drop-wise addition of methanol (100 mL) and then concentrated in vacuo to give (S)-2-hydroxymethyl-piperazine-l,4-dicarboxylic acid di-tert-buty{ ester (12.07 g, 127%) as a white solid which was used without further purification. Analytical LCMS: purity 100% (System C, Rτ = 2.08 min), ES+: 339.4 [MH]+.
References:
WO2009/71658,2009,A1 Location in patent:Page/Page column 26
958635-19-3
33 suppliers
$59.00/250mg
958635-12-6
19 suppliers
$326.00/1g
24424-99-5
826 suppliers
$13.50/25G
958635-12-6
19 suppliers
$326.00/1g
147650-70-2
158 suppliers
$15.00/250mg
958635-12-6
19 suppliers
$326.00/1g