2-Propen-1-one, 1-phenyl-3-(phenylsulfonyl)-, (2E)- synthesis

6synthesis methods

Product Name:2-Propen-1-one, 1-phenyl-3-(phenylsulfonyl)-, (2E)-
CAS Number:960-41-8
Molecular formula:C15H12O3S
Molecular Weight:272.32

873-55-2 Synthesis

873-55-2
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3623-15-2 Synthesis

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2-Propen-1-one, 1-phenyl-3-(phenylsulfonyl)-, (2E)-

960-41-8
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Yield:960-41-8 97 %

Reaction Conditions:

with para-chlorobenzoic acid in 1,3,5-trimethyl-benzene at 30;Schlenk technique;Sealed tube;

Steps:

4 The preparation method comprises the following steps:

Weigh 4-chlorobenzoic acid (62.6mg, 0.4mmol), 1-phenyl-2-propyn-1-one (26.0mg, 0.2mmol) and sodium benzenesulfinate (82.1mg, 0.5mmol) on a belt Add 3.0mL of mesitylene to a 10mL Schlenk tube with a magnet, then seal it and react at 30°C for 48h. After the reaction, the mixed system was filtered through a sand core funnel with silica gel, and the filter residue was washed with 20 mL of ethyl acetate. The resulting filtrate and washings were concentrated under reduced pressure to obtain a residue, which was purified and separated by column chromatography to obtain a pyridine product; the column chromatography Use 200-300 mesh silica gel for separation, and use petroleum ether:ethyl acetate as the mobile phase, with a volume ratio of 4:1. The obtained target product is a yellow solid; 97% yield

References:

CN115197108,2022,A Location in patent:Paragraph 0086-0094

4187-87-5 Synthesis