Methyl 1-benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate synthesis
- Product Name:Methyl 1-benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate
- CAS Number:96124-43-5
- Molecular formula:C13H13NO4
- Molecular Weight:247.25
Yield:96124-43-5 88.37%
Reaction Conditions:
with sodium methylate for 6 h;Reflux;
Steps:
2 Preparation of compound II-A1:
Compound I-1 (18.00g, 1.0eq), dimethyl oxalate (13.20g, 1.20eq), 30% sodium methoxide solution (20.13g, 1.20eq) were added to the reaction flask, and the reaction was heated and refluxed for 6h.After the TLC control reaction was over, the methanol was removed by concentration, 200ml of water was added to the residual liquid and stirred for 5 minutes, HCl solution was added dropwise to adjust the pH=6, and the mixture was stirred for 30 minutes.Suction filtration to obtain 19.2g of crude filter cake, add 200ml of methanol to the crude product and heat to reflux for 1h.After cooling to room temperature, the compound II-A1 was obtained after suction filtration: 16.8 g of white solid, the yield was 88.37%,
References:
CN111793017,2020,A Location in patent:Paragraph 0074-0077
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