2-BUTYL-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOLE-5-CARBOXYLIC ACID synthesis

Yield:-

Reaction Conditions:

with acetic acid at 100;

Steps:

4.1.1 General procedure for preparation of compounds 3a-l

General procedure: mixture of (1,3-dioxo-1,3-dihydrobenzofuran-5-carboxylic acid) compound 1 (2mmol) and compound 2 (2mmol) in acetic acid (10ml) was reflux at 100°C for 6h. After the reaction was completed, the reaction mixture was cooled to room temperature, and ice water was added to it with stirring for 30min (if the reaction did not precipitate, K₂CO₃ solution was added slowly), and the separated solid was filtered and then dried

References:

Kakakhan, Chnar;Türke?, Cüneyt;Güle?, ?zcan;Demir, Yeliz;Arslan, Mustafa;?zkemahl?, Gizem;Beydemir, ?ükrü [Bioorganic and Medicinal Chemistry,2023,vol. 77,art. no. 117111]