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1-(4-METHYL-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID synthesis

2synthesis methods
-

Yield:96449-91-1 92%

Reaction Conditions:

at 120; for 4 h;

Steps:

64-1 (64-1)

(64-1)
Synthesis of 1-[(4-chlorophenyl)methyl]-5-pyrrolidine-3-carboxylic acid (Compound 64-1)
A mixture of itaconic acid (1.3 g, 10 mmol) and p-chlorobenzylamine (1.28 ml, 11 mmol) was stirred at 120 °C for 4 hours.
Thereafter, the solvent was evaporated off under reduced pressure, and the obtained crystals were washed with a mixed solution of acetic acid and hexane (1:9) to obtain the title compound (2.3 g, yield 92%).

References:

EP3275440,2018,A1 Location in patent:Paragraph 0155; 0156

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