2-Amino-4,5,6,7-tetrahydro-7-oxobenzo[b]thiophene-3-carbonitrile synthesis
1synthesis methods
- Product Name:2-Amino-4,5,6,7-tetrahydro-7-oxobenzo[b]thiophene-3-carbonitrile
- CAS Number:98899-30-0
- Molecular formula:C9H8N2OS
- Molecular Weight:192.24
Yield:98899-30-0 76%
Reaction Conditions:
Stage #1: 1,3-cylohexanedione;malononitrilewith triethylamine in ethanol; for 4 h;Reflux;Gewald Aminoheterocycles Synthesis;
Stage #2: with sulfur;diethylamine in ethanol; for 4 h;Reflux;Gewald Aminoheterocycles Synthesis;
References:
Wang, Zhong-Xia;Chen, Li-Zhuang;Li, Bei;Han, Guang-Fan [Journal of Heterocyclic Chemistry,2015,vol. 52,# 6,p. 1663 - 1668]