9H-Carbazole, 9-ethyl-3-iodo- synthesis

7synthesis methods

Product Name:9H-Carbazole, 9-ethyl-3-iodo-
CAS Number:50668-21-8
Molecular formula:C14H12IN
Molecular Weight:321.16

74-96-4 Synthesis

74-96-4
433 suppliers
$9.00/5g

16807-13-9
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$9.00/1g

50668-21-8
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$28.60/50mg

Yield:50668-21-8 Ca. 91 %

Reaction Conditions:

Stage #1: 3-iodocarbazolewith potassium hydroxide in acetone at 20;
Stage #2: ethyl bromide in acetone at 20;

Steps:

1 Step 1:

KOH (340.58mmol, 19.11g) was dissolved in acetone (250mL), stirred at room temperature for 20min, then 3-iodocarbazole (68.26mmol, 20.00g) was added to the above solution, stirred at room temperature for 3h, Subsequently, the acetone (50mL) solution containing bromoethane (204.77mmol, 22.32g) was added dropwise to the above solution, stirred at room temperature, and after the completion of the reaction of 3-iodocarbazole monitored by TLC, concentrated under reduced pressure to remove most of the Acetone solvent, add saturated saline and ethyl acetate to extract, the organic phase is dried with anhydrous sodium sulfate, add silica gel powder and distill under reduced pressure to prepare samples, petroleum ether: ethyl acetate = 20:1 (V/V) as elution Reagent was purified by column to obtain compound 1 with a yield of about 91%.

References:

CN115650963,2023,A Location in patent:Paragraph 0009