AcetaMide, 2-(propylaMino)- (hydrochloride)(1:1) synthesis
1synthesis methods
- Product Name:AcetaMide, 2-(propylaMino)- (hydrochloride)(1:1)
- CAS Number:1228879-13-7
- Molecular formula:C5H13ClN2O
- Molecular Weight:152.6225
Yield:1228879-13-7 69%
Reaction Conditions:
in acetonitrile at 0 - 20;
Steps:
178.A
To a solution of propan-1 -amine (236 g, 3.99 mol) in acetonitrile (100 mL) at 0 0C was added a solution of 2- chloroacetamide (93.6 g, 1.00 mol) in acetonitrile (1500 mL) over 3 h. The resulting mixture was warmed to room temperature and stirred overnight. The reaction mixture was concentrated under reduced pressure to give the crude material that was purified by re-crystallization (MeOH and CH2Cl2) to afford 80 g (69%) of 2-(propylamino)acetamide as HCl salt. LCMS ESI (+) m/z 117 (M+ 1) detected.
References:
WO2011/22509,2011,A2 Location in patent:Page/Page column 89-90