Acetamide, N-(4-chloro-3-(trifluoromethyl)phenyl)- synthesis

Yield:348-90-3 99 %

Reaction Conditions:

in acetic acid at 0;Temperature;

Steps:

1.1; 2.1; 3.1 (1) Synthesis of compound III

Add 195g (1.0mol) 3-trifluoromethyl-4-chloroaniline and 1500ml acetic acid to the reaction flask, drop the temperature to 0°C and add 122.4g (1.2mol) acetic anhydride dropwise, keep stirring for 5h after dropping, and follow the reaction by HPLC until The reaction of 3-trifluoromethyl-4-chloroaniline was complete; 1000ml of water was added to quench the reaction, and a solid was precipitated, which was filtered and dried to obtain 234.6g of compound III, with a molar yield of 99.0%.

References:

CN115433093,2022,A Location in patent:Paragraph 0008; 0031-0094; 0046-0049; 0059-0062