![](/CAS/GIF/59-66-5.gif)
Acetazolamide synthesis
- Product Name:Acetazolamide
- CAS Number:59-66-5
- Molecular formula:C4H6N4O3S2
- Molecular Weight:222.25
![2-(ACETAMIDO)-5-(CHLOROSULFONYL)-1,3,4-THIADIAZOLE](/CAS/GIF/32873-57-7.gif)
32873-57-7
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![Acetazolamide](/CAS/GIF/59-66-5.gif)
59-66-5
384 suppliers
$11.00/1g
Yield:59-66-5 74%
Reaction Conditions:
with 1,1,1-triphenylsilylamine in acetonitrile for 1 h;Reflux;Inert atmosphere;
Steps:
Preparation of sulfonamide products
General procedure: The sulfonyl chloride (1mmol) is dissolved in 15 ml acetonitrile and then silylamine (1 mmol) is addedslowly. The reaction mixture is refluxed for 1 hour and concentrated withrotary evaporator. If necessary, the product may be further purified by silicagel chromatography (hexane: ethyl acetate).
References:
Naredla, Rajasekhar Reddy;Klumpp, Douglas A. [Tetrahedron Letters,2013,vol. 54,# 45,p. 5945 - 5947] Location in patent:supporting information
![2-ACETAMIDO-5-BENZYLTHIO-1 3 4-](/CAS/GIF/64387-67-3.gif)
64387-67-3
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$165.00/1g
![Acetazolamide](/CAS/GIF/59-66-5.gif)
59-66-5
384 suppliers
$11.00/1g
![5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE](/CAS/GIF/14949-00-9.gif)
14949-00-9
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$60.00/100 mg
![Thioacetic acid](/CAS/GIF/507-09-5.gif)
507-09-5
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$12.00/5g
![Acetazolamide](/CAS/GIF/59-66-5.gif)
59-66-5
384 suppliers
$11.00/1g