ACETYL ACETOSYRINGONE synthesis
- Product Name:ACETYL ACETOSYRINGONE
- CAS Number:28294-47-5
- Molecular formula:C12H14O5
- Molecular Weight:238.24
2478-38-8
309 suppliers
$5.00/50mg
75-36-5
562 suppliers
$17.92/100G
28294-47-5
15 suppliers
$28.60/50MG
Yield:28294-47-5 99%
Reaction Conditions:
with potassium carbonate;triethylamine in dichloromethane;
Steps:
331.1 331.1
331.1 4-acetyl-2,6-dimethoxyphenyl acetate 3.0 g (15.3 mmol) of 3,5-dimethoxy-4-hydroxyacetophenone is dissolved in dichloromethane (30 ml) and 2.53 g (18.3 mmol) of K2CO3 is added. Triethylamine (2.6 ml) is then added dropwise. The reaction medium is cooled down to 0° C. and acetyl chloride (1.31 ml; 18.3 mmol) is added. The mixture is stirred for 24 hours at ambient temperature then poured into ice-cooled water. After extraction with dichloromethane, the organic phase is washed with sodium chloride in a saturated aqueous solution before being dried over magnesium sulphate, filtered and concentrated under vacuum. The product obtained is purified by crystallization from ether in order to produce a white solid with a yield of 99%. Melting point: 145° C.
References:
US2004/132788,2004,A1 US2005/38087,2005,A1
2478-38-8
309 suppliers
$5.00/50mg
127-09-3
1059 suppliers
$8.00/100dtn(0.82g)
28294-47-5
15 suppliers
$28.60/50MG
2478-38-8
309 suppliers
$5.00/50mg
108-24-7
5 suppliers
$14.00/250ML
28294-47-5
15 suppliers
$28.60/50MG