ChemicalBook CAS DataBase List AFMK

AFMK synthesis

9synthesis methods

Product Name:AFMK
CAS Number:52450-38-1
Molecular formula:C13H16N2O4
Molecular Weight:264.28

73-31-4 Synthesis

73-31-4
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$6.00/1g

52450-38-1
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$18.00/1mg

Yield: 55%

Reaction Conditions:

with sodium periodate in methanol;water at 0 - 80; for 12 h;

Steps:

4.1.2 N-(2-(3-(1,3-dioxoisoindolin-2-yl)propanoyl)-4-methoxyphenyl)formamide (2)
General procedure: To solution of 1 (437mg, 1.36mmol) in methanol (26mL) was added dropwise a solution of NaIO₄ (1.17g, 5.46mmol) in water (30mL) at 0°C. The mixture was stirred at 80°C for 12h and concentrated under vacuum. The residue was putted into water (25mL) and extracted with DCM (3×50mL). The combined organic layers were dried over MgSO₄ and evaporated. The residue was purified by flash chromatography (PE/AcOEt); 10:0 to 7:3 (v/v)) to afford 2 as a brown powder (71% yield).

References:

Bolteau, Raphaël;Descamps, Florian;Ettaoussi, Mohamed;Caignard, Daniel H.;Delagrange, Philippe;Melnyk, Patricia;Yous, Saïd [European Journal of Medicinal Chemistry,2020,vol. 189,art. no. 112078]

64-18-6 Synthesis