AKOS 227-02 synthesis

Yield:5651-55-8 27 mg

Reaction Conditions:

with methanol;water;lithium hydroxide at 20;

References:

Wu, Yu-Shan;Coumar, Mohane Selvaraj;Chang, Jang-Yang;Sun, Hsu-Yi;Kuo, Fu-Ming;Kuo, Ching-Chuan;Chen, Ying-Jun;Chang, Chi-Yen;Hsiao, Chia-Ling;Liou, Jing-Ping;Chen, Ching-Ping;Yao, Hsien-Tsung;Chiang, Yi-Kun;Tan, Uan-Kang;Chen, Chiung-Tong;Chu, Chang-Ying;Wu, Su-Ying;Yeh, Teng-Kuang;Lin, Chin-Yu;Hsieh, Hsing-Pang [Journal of Medicinal Chemistry,2009,vol. 52,# 15,p. 4941 - 4945] Location in patent:supporting information; experimental part