ChemicalBook CAS DataBase List AKOS 243-39

AKOS 243-39 synthesis

13synthesis methods

Product Name:AKOS 243-39
CAS Number:6328-77-4
Molecular formula:C15H15NO
Molecular Weight:225.29

98-91-9 Synthesis

98-91-9
152 suppliers
$11.00/25g

95-68-1
312 suppliers
$14.00/5g

6328-77-4
5 suppliers
$134.00/250mg

Yield:6328-77-4 81%

Reaction Conditions:

with oxygen;3,6-di(2'-pyridyl)-1,2,4,5-tetrazine in tetrahydrofuran at 20; for 5 h;

Steps:

General experimental procedure for the synthesis of amide

General procedure: Thioacids (1 mmol, 1.0 equiv.), pytz (0.1 mmol, 0.1 equiv.) in THF (5 mL) were placed in a 50 mL round bottom flask and amines (1 mmol, 1.0 equiv.) dissolved in 5 mL THF was then added to it slowly under oxygen. The reaction mixture was stirred at room temperature for 4-7 h. When the reaction was completed (monitored by TLC), reaction mixture was evaporate to dryness at room temperature under vacuum. The residue was re-dissolved in chloroform (5 mL), washed with water and brine and dried over anhydrous Na₂SO₄. After filtration and removal of solvent, the residue was purified by flash column chromatography (hexane/ethyl acetate, 10:1) to afford the desired products 3aa-3as, 3ba-3bc, 3bt.

References:

Samanta, Suvendu;Ray, Shounak;Bhaduri, Samanka Narayan;Samanta, Partha Kumar;Biswas, Papu [Tetrahedron Letters,2020,vol. 61,# 35,art. no. 152272] Location in patent:supporting information