AKOS B018302 synthesis

Yield:349-33-7 95%

Reaction Conditions:

with sodium acetate in acetic acid at 110; for 0.266667 h;Microwave irradiation;Knoevenagel Condensation;

Steps:

General procedure for the synthesis of compounds (3a-l) Method A: Microwave-assisted synthesis:

General procedure: In a 100 ml round bottom flask, equimolar amounts of 2-thioxothiazolidin-4-one 1 (1 mmol), anhydrous sodium acetate (1 mmol) were added in glacial acetic acid (1 mL) and then aromatic aldehydes 2a-l (1 mmol) were added to the reaction mixture. This mixture was subjected to MW irradiation (800 W), at 110 °C temperature for 14-18 min. The progress of reaction was monitored by TLC (20% ethyl acetate: n-hexane). After completion of the reaction, the reaction mixture was poured into the ice-cold water. The precipitate was filtered off and washed with water (3 × 15 mL), dried, and purified by recrystallization in ethanol as solvent to give 92-98% yield.

References:

Pansare, Dattatraya N.;Shinde, Devanand B. [Tetrahedron Letters,2014,vol. 55,# 5,p. 1107 - 1110] Location in patent:supporting information