AKOS B018368 synthesis
- Product Name:AKOS B018368
- CAS Number:28824-66-0
- Molecular formula:C11H7NO3S2
- Molecular Weight:265.31
Yield:28824-66-0 95%
Reaction Conditions:
with boric acid in neat (no solvent) at 160; for 0.666667 h;Microwave irradiation;Sealed tube;Green chemistry;stereoselective reaction;
Steps:
3.1. General Procedure for the Condensation Reaction
General procedure: A mixture of substrate (1 mmol), aldehyde (1.2 mmol) and boric acid (0.2 mmol) was placed in a cylindrical quartz reactor ( θ = 4 cm). The reactor was introduced into an Explorer24 CEM apparatus. The stirred mixture was heated at 160 °C (P = 300 W) for 40 min, except for 3c (180 °C). After microwave dielectric heating, the crude reaction mixture was allowed to cool down at room temperature and ethanol (10 mL) or mixture of H2O/EtOH (10 mL) was directly added in the cylindrical quartz reactor. The resulting precipitated product was filtered off and was purified by recrystallization from ethanol if necessary.
References:
Brun, Elodie;Safer, Abdelmounaim;Carreaux, Franois;Bourahla, Khadidja;L'Helgoua'ch, Jean-Martial;Bazureau, Jean-Pierre;Villalgordo, Jose Manuel [Molecules,2015,vol. 20,# 6,p. 11617 - 11631]
139-85-5
818 suppliers
$5.00/1g
28824-66-0
17 suppliers
$45.00/50mg
141-84-4
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$8.00/5g
111-42-2
820 suppliers
$10.00/20mg
28824-66-0
17 suppliers
$45.00/50mg