AKOS B028995 synthesis
- Product Name:AKOS B028995
- CAS Number:215124-03-1
- Molecular formula:C7H4ClIO2
- Molecular Weight:282.46
635-93-8
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$6.00/5g
215124-03-1
26 suppliers
$31.00/250mg
Yield:215124-03-1 94%
Reaction Conditions:
with N-iodo-succinimide in acetic acid at 95; for 3 h;
Steps:
Scheme VI depicts a method for preparing aldehyde 15. For example, a mixture of an aldehyde of formula 14 wherein R3 and R5 are hydrogen, i.e., 5-chloro,2-hydroxy benzaldehyde (0.10 g, 0.64 mmol) and N-iodosuccinimide (0.16 g, 0.71 mmol) in acetic acid (2 mL) was heated to 95° C. for 2 h. Another portion of N-iodosuccinimide (0.020 g, 0.09 mmol) was added and heating was continued for 1 h. The mixture was diluted with ethyl acetate, washed in succession with 5% aqueous Na2S2O3, saturated NaCl, and dried (Na2SO4). The solvent was removed under reduced pressure, and 5-chloro-3-iodo-benzaldehyde was obtained as a yellow crystalline solid (0.17 g, 94%)
References:
US6867200,2005,B1 Location in patent:Page/Page column 22
71643-66-8
135 suppliers
$6.00/250mg
215124-03-1
26 suppliers
$31.00/250mg