AKOS BBS-00005392 synthesis

Yield:30355-06-7 70%

Reaction Conditions:

with sodium hydrogencarbonate in water at 20; pH=7; for 4 h;

Steps:

6-chloro-N²,N⁴-bis(3,4-dichlorophenyl)-1,3,5-triazine-2,4-diamine 9

To a stirred solution of the cyanuric chloride (184mg, 1 mmol, 1.0 equiv.) in 1 mL acetone was added 3,4-dichloroaniline (324 mg,2 mmol, 2.0 equiv.). Saturated aqueous sodium bicarbonate wasadded to keep pH 7.0. After stirring at room temperature for 4 h, the reactionmixture was poured into 3.0 mL ice water. The precipitate was filtered, washedwith water, and dried in vacuo to afford 9 as a white solid (305 mg, 70%yield).

References:

Yao, Houzong;Liu, Fengyou;Chen, Jinglei;Li, Yan;Cui, Jinhao;Qiao, Chunhua [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 5,p. 1386 - 1390] Location in patent:supporting information