AKOS BBS-00006184 synthesis
- Product Name:AKOS BBS-00006184
- CAS Number:879927-52-3
- Molecular formula:C11H9ClO3
- Molecular Weight:224.64
504-15-4
375 suppliers
$7.00/100mg
638-07-3
469 suppliers
$5.00/5G
879927-52-3
8 suppliers
$393.00/1g
Yield:879927-52-3 89%
Reaction Conditions:
with Ag supported on the hydroxyapatite-core-shell magnetic γ-Fe2O3 nanoparticles in neat (no solvent) at 80; for 0.3 h;Green chemistry;Pechmann Condensation;
Steps:
2.2. General procedure for the Pechmann condensation
General procedure: In a round bottom flask, g-Fe2O3HAp-Ag NPs (10 mg) were added to the mixture of the phenolic compound (1 mmol) and ethyl acetoacetate (1 mmol) at 80 C and the reaction mixture stirred for the appropriate time (Table 3). The progress of the reaction was monitored by TLC (eluent, n-hexane:ethyl acetate, 4:1) analysis. Upon completion of the reaction, EtOH was added to the reaction mixture and the g-Fe2O3HAp-Ag NPs were separated with an external magnet. The solvent was then removed under reduced pressure and the resulting product was purified by recrystallization using ethanol. The coumarin derivatives were obtained in good to excellent isolated yields (83%-96%).
References:
Abbasi, Zahra;Rezayati, Sobhan;Bagheri, Maryam;Hajinasiri, Rahimeh [Chinese Chemical Letters,2017,vol. 28,# 1,p. 75 - 82]
