Alanine, 2-methyl-, butyl ester synthesis
- Product Name:Alanine, 2-methyl-, butyl ester
- CAS Number:16252-91-8
- Molecular formula:C8H17NO2
- Molecular Weight:159.23
Yield:16252-91-8 1.34 g
Reaction Conditions:
with thionyl chloride for 5.5 h;Reflux;
Steps:
9.1 Example 9 Synthesis of Compound I-9
1) Add 2-methylalanine (1.00g) to n-butanol (7.18g),Thionyl chloride (1.38g) was added dropwise at room temperature, and the solution was refluxed for 5.5h after completion.Concentrate under reduced pressure, the residue is adjusted to neutral pH with potassium bicarbonate solution,Dichloromethane extraction (50 mL) 3 times, the dichloromethane layers were combined and washed with saturated brine,Dried over anhydrous sodium sulfate, and concentrated under reduced pressure,2-Methylalanine n-butyl ester (1.34 g) was obtained.
References:
CN110938095,2020,A Location in patent:Paragraph 0110-0112
