Albutoin synthesis

Yield:-

Steps:

Multi-step reaction with 4 steps
1: pyridine / water
2: triethylamine; dacarbazine / dichloromethane
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 8 h
4: water / aq. buffer / 20 h / 37 °C / pH 6.5

References:

Krasnovskaya, Olga O.;Malinnikov, Vladislav M.;Dashkova, Natalia S.;Gerasimov, Vasily M.;Grishina, Irina V.;Kireev, Igor I.;Lavrushkina, Svetlana V.;Panchenko, Pavel A.;Zakharko, Marina A.;Ignatov, Pavel A.;Fedorova, Olga A.;Jonusauskas, Gediminas;Skvortsov, Dmitry A.;Kovalev, Sergey S.;Beloglazkina, Elena K.;Zyk, Nikolay V.;Majouga, Alexander G. [Bioconjugate Chemistry,2019,vol. 30,# 3,p. 741 - 750]