Ald-PEG3-Azide synthesis

Yield: 66%

Reaction Conditions:

Stage #1:2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol with oxalyl dichloride in tetrahydrofuran;dimethyl sulfoxide at -78; for 0.5 h;Inert atmosphere;
Stage #2: with triethylamine in tetrahydrofuran;dimethyl sulfoxide at -78; for 0.25 h;Inert atmosphere;

References:

Sornay, Charlotte;Hessmann, Steve;Erb, Stéphane;Dovgan, Igor;Ehkirch, Anthony;Botzanowski, Thomas;Cianférani, Sarah;Wagner, Alain;Chaubet, Guilhem [Chemistry - A European Journal,2020,vol. 26,# 61,p. 13797 - 13805] Location in patent:supporting information