![](/CAS/GIF/16212-05-8.gif)
Allyl phenyl sulfone synthesis
- Product Name:Allyl phenyl sulfone
- CAS Number:16212-05-8
- Molecular formula:C9H10O2S
- Molecular Weight:182.24
![Phenyl vinyl sulfone](/CAS/GIF/5535-48-8.gif)
5535-48-8
258 suppliers
$12.00/1g
![Allyl bromide](/CAS/GIF/106-95-6.gif)
106-95-6
418 suppliers
$10.00/5g
![Allyl phenyl sulfone](/CAS/GIF/16212-05-8.gif)
16212-05-8
136 suppliers
$14.00/250mg
Yield: 92%
Reaction Conditions:
Stage #1:PVS with tetraethylammoniumcyanide in dichloromethane for 0.0833333 h;
Stage #2:allyl bromide in dichloromethane at 20;
Steps:
General Procedure for the Synthesis of Sulfones 2a–m
General procedure: Vinyl sulfone (0.4 mmol) and tetraethylammonium cyanide(1.05 equiv, 0.42 mmol) were dissolved in DCM (1 mL). Thereaction mixture was stirred for 5 min, and a solution of an appropriate electrophile (1.05 equiv, 0.42 mmol) in DCM (0.5mL) was added dropwise. The resultant reaction mixture wasstirred at room temperature. After completion of the reaction(checked by crude 1H NMR or GC–MS), water (10 mL) was addedto the reaction mixture, and the product was extracted withethyl acetate (3 × 10 mL). The combined organic layers werewashed with brine (10 mL), dried over anhydrous Na2SO4, andconcentrated under vacuum. The crude product thus obtainedwas purified by column chromatography using 10–20percent ethylacetate in petroleum ether.
References:
Lee, Ji-Woong;Roy, Tamal [Synlett,2020,vol. 31,# 5,p. 455 - 458]
![ALLYL PHENYL SULFIDE](/CAS/GIF/5296-64-0.gif)
5296-64-0
77 suppliers
$25.00/5g
![Allyl phenyl sulfone](/CAS/GIF/16212-05-8.gif)
16212-05-8
136 suppliers
$14.00/250mg
![BENZENETHIOSULFONIC ACID S-PHENYL ESTER](/CAS/GIF/1212-08-4.gif)
1212-08-4
84 suppliers
$132.00/1g
![Allyl bromide](/CAS/GIF/106-95-6.gif)
106-95-6
418 suppliers
$10.00/5g
![Allyl phenyl sulfone](/CAS/GIF/16212-05-8.gif)
16212-05-8
136 suppliers
$14.00/250mg
![ALLYL PHENYL SULFIDE](/CAS/GIF/5296-64-0.gif)
5296-64-0
77 suppliers
$25.00/5g
![Allyl phenyl sulfone](/CAS/GIF/16212-05-8.gif)
16212-05-8
136 suppliers
$14.00/250mg
![ALLYL PHENYL SULFOXIDE](/CAS/GIF/19093-37-9.gif)
19093-37-9
17 suppliers
inquiry
![ALLYL PHENYL SULFIDE](/CAS/GIF/5296-64-0.gif)
5296-64-0
77 suppliers
$25.00/5g
![Allyl phenyl sulfone](/CAS/GIF/16212-05-8.gif)
16212-05-8
136 suppliers
$14.00/250mg
![ALLYL PHENYL SULFOXIDE](/CAS/GIF/19093-37-9.gif)
19093-37-9
17 suppliers
inquiry