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ChemicalBook CAS DataBase List alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol
17781-31-6

alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol synthesis

2synthesis methods
-

Yield:17781-31-6 46%

Reaction Conditions:

with n-butyllithium in tetrahydrofuran;hexane at -80 - 20;Inert atmosphere;

References:

Keenan, Martine;Abbott, Michael J.;Alexander, Paul W.;Armstrong, Tanya;Best, Wayne M.;Berven, Bradley;Botero, Adriana;Chaplin, Jason H.;Charman, Susan A.;Chatelain, Eric;Von Geldern, Thomas W.;Kerfoot, Maria;Khong, Andrea;Nguyen, Tien;McManus, Joshua D.;Morizzi, Julia;Ryan, Eileen;Scandale, Ivan;Thompson, R. Andrew;Wang, Sen Z.;White, Karen L. [Journal of Medicinal Chemistry,2012,vol. 55,# 9,p. 4189 - 4204] Location in patent:experimental part