ALPHA-CHLORO-2-FLUOROBENZALDOXIME synthesis
- Product Name:ALPHA-CHLORO-2-FLUOROBENZALDOXIME
- CAS Number:39502-43-7
- Molecular formula:C7H5ClFNO
- Molecular Weight:173.57
24652-66-2
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Yield:39502-43-7 90%
Reaction Conditions:
with N-chloro-succinimide in N,N-dimethyl-formamide at 10 - 20; for 4 h;
Steps:
130 Preparation 130: 2-fluoro-N-hydroxybenzimidoyl chloride
NCS (26.39 g, 197.66 mmol) was added portion wise to a stirred solution of 421 (E)-2-fluorobenzaldehyde oxime (Preparation 131, 25.0 g, 179.69 mmol) in 21 DMF (50 mL) at 10-20° C. The reaction mixture was stirred at rt for 4 hrs, diluted with water and extracted with Et20. The combined organic extracts were washed with water, then brine, dried (Na2SO4) and evaporated to dryness in vacuo to afford the 210 title compound (28 g, 90%) as a white gummy liquid. 1HNMR (400 MHz, DMSO-d6) 7.32 (m, 2H), 7.54 (m, 1H), 7.64 (m, 1H), 12.61 (s, 1H)
References:
US2018/141954,2018,A1 Location in patent:Paragraph 0552; 0553
446-52-6
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