ChemicalBook CAS DataBase List alpha-Hydroxybenzenepropanoic acid methyl ester

alpha-Hydroxybenzenepropanoic acid methyl ester synthesis

9synthesis methods

Product Name:alpha-Hydroxybenzenepropanoic acid methyl ester
CAS Number:13673-95-5
Molecular formula:C10H12O3
Molecular Weight:180.2

20312-36-1
225 suppliers
$5.00/1g

alpha-Hydroxybenzenepropanoic acid methyl ester

13673-95-5
105 suppliers
$6.00/1g

Yield:13673-95-5 98%

Reaction Conditions:

with toluene-4-sulfonic acid in methanol; for 17 h;Heating / reflux;

Steps:

7 EXAMPLE 7. (S)-2-Hydroxy-3-phenylpropionic acid, methyl ester

A solution of commercially available (S)-2-hydroxy-3-phenylpropionic acid (5.0 g, 30.1 mmol) and p-toluenesulfonic acid hydrate (1 g) in methanol (125 mL) was refluxed with removal of water using 3A molecular sieves for 17 h. The solution was concentrated and dissolved in ether. The ether solution was washed with saturated sodium bicarbonate, brine and concentrated to provide the title compound as a white solid (5.32 g, 98%): NMR (CDCl3); δ7.36-7.20 (m, 5H), 4.47 (ddd, J=5, 6, 7 Hz, 1H), 3.78 (s, 3H), 3.14 (dd, J=5, 14 Hz, 1H), 2.97 ( dd, J=7, 14 Hz), 2.69 (d, J=6 Hz, 1H).

References:

US6340676,2002,B2 Location in patent:Page column 20

67-56-1 Synthesis