alpha-Hydroxybenzenepropanoic acid methyl ester synthesis
- Product Name:alpha-Hydroxybenzenepropanoic acid methyl ester
- CAS Number:13673-95-5
- Molecular formula:C10H12O3
- Molecular Weight:180.2
20312-36-1
235 suppliers
$5.00/1g
13673-95-5
106 suppliers
$6.00/1g
Yield:13673-95-5 98%
Reaction Conditions:
with toluene-4-sulfonic acid in methanol; for 17 h;Heating / reflux;
Steps:
7 EXAMPLE 7. (S)-2-Hydroxy-3-phenylpropionic acid, methyl ester
A solution of commercially available (S)-2-hydroxy-3-phenylpropionic acid (5.0 g, 30.1 mmol) and p-toluenesulfonic acid hydrate (1 g) in methanol (125 mL) was refluxed with removal of water using 3A molecular sieves for 17 h. The solution was concentrated and dissolved in ether. The ether solution was washed with saturated sodium bicarbonate, brine and concentrated to provide the title compound as a white solid (5.32 g, 98%): NMR (CDCl3); δ7.36-7.20 (m, 5H), 4.47 (ddd, J=5, 6, 7 Hz, 1H), 3.78 (s, 3H), 3.14 (dd, J=5, 14 Hz, 1H), 2.97 ( dd, J=7, 14 Hz), 2.69 (d, J=6 Hz, 1H).
References:
US6340676,2002,B2 Location in patent:Page column 20
67-56-1
772 suppliers
$9.00/25ml
20312-36-1
235 suppliers
$5.00/1g
13673-95-5
106 suppliers
$6.00/1g
156-06-9
184 suppliers
$45.00/1g
13673-95-5
106 suppliers
$6.00/1g