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AMINO-(4-DIMETHYLAMINO-PHENYL)-ACETIC ACID synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium hydroxide / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
2: (S)-2-amino-(2-chlorophenyl)ethanoic acid / water; acetonitrile / 84 h / 50 °C / Reflux; Inert atmosphere

References:

Inada, Haruki;Shibuya, Masatoshi;Yamamoto, Yoshihiko [Journal of Organic Chemistry,2020,vol. 85,# 17,p. 11047 - 11059]