![](/CAS/GIF/125-84-8.gif)
Aminoglutethimide synthesis
- Product Name:Aminoglutethimide
- CAS Number:125-84-8
- Molecular formula:C13H16N2O2
- Molecular Weight:232.28
![CB5131691-1.jpg CB5131691-1.jpg](/NewsImg/2021-08-20/6376507509505264926640914.jpg)
The second method starts with 2-phenylbutyronitrile, which is nitrated under analogous conditions, forming 2-(4-nitrophenyl)butyronitrile (30.5.5). The last, in Michael addition reaction conditions, in the presence of benzyltrimethylammonia hydroxide is added to methylacrylate, and the obtained product undergoes acidic hydrolysis by a mixture of acetic and sulfuric acids, during which a cyclyzation to 2-(4-nitrophenyl)-2-ethylglutarimide (30.5.3) occurs, and this product is reduced by hydrogen by the analogy to that described above, to give the desired product aminoglutethimide (30.5.4) .
![CB5131691-2.jpg CB5131691-2.jpg](/NewsImg/2021-08-20/6376507510803439175893535.jpg)
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$19.50/5mg